姓名：金萃媛
职称：特聘副研究员
电子邮箱：jincuiyuan@zjstu.edu.cn
办公地点：浙江树人学院拱宸桥校区26号楼
研究领域：肠道菌群紊乱的致病机理、遗传代谢疾病、环境毒理学等
1. 个人简介：
2019年毕业于浙江工业大学生物工程学院，获得工学博士学位，同年进入浙江工业大学生物资源与生物环保研究所从事博士后研究，主要从事环境污染物对青春期小鼠及小鼠传代过程中肠道菌群、肠道屏障及相关功能的研究工作。2021年12月受聘于浙江树人学院转化医学研究院任特聘副研究员，研究领域主要包括肠道菌群紊乱的致病机理、遗传代谢疾病、环境毒理学等。以一作（共一）或通讯在主流刊物如Gut、Journal of Hazardous Materials、Science of the Total Environment、Toxicological Sciences、Chemosphere等杂志发表学术论文十一篇，其他合作发表论文十余篇，主持国自然青年基金和浙江省博士后科研项目一等资助等研究项目。
2. 代表性论文:
(1) Wang Xiao, Hu Lingyu, Wang Caiyun, He Bingnan, Fu Zhengwei, Jin Cuiyuan*（金萃媛，共同通讯）, Jin, Yuanxiang*. Cross-generational effects of maternal exposure to imazalil on anaerobic components and carnitine absorption associated with OCTN2 expression in mice. Chemosphere. 2022, 308(Pt 3): 136542.
(2) Lou Mingxing1, Cao Aihua1, Jin Cuiyuan1（金萃媛，共一）, Mi Kai1, Xiong Xiyue, Zeng Zhaoyang, Pan Xu, Qie Jinlong, Qiu Shangfeng, Niu Yaofang, Liang Hao, Liu Yanping, Chen Lin, Liu Zhi, Qiu Xiyan, Jin Yuanxiang, Sheng Xiaoqi, Hu Zhibin, Jin Gulei*, Liu Jingshi*, Liu Xingyin*, Wang Yichao*. Deviated and early unsustainable stunted development of gut microbiota in children with autism spectrum disorder. Gut. 2022, 71(8): 1588-1599.
(3) Jin Cuiyuan（金萃媛）, Weng You, Zhang Yi, Bao Zhiwei, Yang Guiling, Fu Zhengwei, Jin Yuanxiang*. Propamocarb exposure has the potential to accelerate the formation of atherosclerosis both in WT and ApoE-/- mice accompanied by gut microbiota dysbiosis. Science of the Total Environment. 2021, 800: 149602.
(4) Jin Cuiyuan（金萃媛）, Yuan Xianling, Wang Caiyun, Fu Zhengwei, Jin Yuanxiang*. Maternal exposure to imazalil disrupts intestinal barrier and bile acids enterohepatic circulation tightly related IL-22 expression in F0, F1 and F2 generations of mice. Journal of Hazardous Materials. 2021, 403: 123668.
(5) Wang Yanhua1, Jin Cuiyuan1（金萃媛，共一）, Wang Dou, Zhou Jiajie, Yang Guiling*, Shao Kan, Wang Qiang*, Jin Yuanxiang*. Effects of chlorothalonil, prochloraz and the combination on intestinal barrier function and glucolipid metabolism in the liver of mice. Journal of Hazardous Materials. 2021, 410: 124639.
(6) Jin Cuiyuan（金萃媛）, Zhang Rui, Fu Zhengwei, Jin Yuanxiang*. Maternal exposure to imazalil disrupts the endocrine system in F1 generation mice. Molecular and Cellular Endocrinology. 2019, 486: 105-112.
(7) Jin Cuiyuan1（金萃媛）, Zeng Zhaoyang1, Wang Caiyun, Luo Ting, Wang Siyu, Zhou Jicong, Ni Yingchun, Fu Zhengwei, Jin Yuanxiang*. Insights into a possible mechanism underlying the connection of carbendazim-Induced lipid metabolism disorder and gut microbiota dysbiosis in mice. Toxicological Sciences. 2018, 166(2): 382-393.
(8) Jin Cuiyuan（金萃媛）, Xia Jizhou, Wu Sisheng, Tu Wenqing, Pan Zihong, Fu Zhengwei, Wang Yueyi, Jin Yuanxiang*. Insights into a possible influence on gut microbiota and intestinal barrier function during chronic exposure of mice to imazalil. Toxicological Sciences. 2018, 162(1): 113-123.
(9) Jin Cuiyuan（金萃媛）, Luo Ting, Fu Zhengwei, Jin Yuanxiang*. Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels. Environmental Toxicology. 2018, 33(6): 650-658.
(10) Jin Cuiyuan（金萃媛）, Luo Ting, Zhu Zhihong, Pan Zihong, Yang Jiajing, Wang Wenchao, Fu Zhengwei, Jin Yuanxiang*. Imazalil exposure induces gut microbiota dysbiosis and hepatic metabolism disorder in zebrafish. Comparative Biochemistry and Physiology C-Toxicology & Pharmacology. 2017, 202: 85-93.
(11) Jin Cuiyuan（金萃媛）, Zeng Zhaoyang, Fu Zhengwei, Jin Yuanxiang*. Oral imazalil exposure induces gut microbiota dysbiosis and colonic inflammation in mice. Chemosphere. 2016, 160: 349-358.
3. 项目资助情况：
(1) 浙江树人大学引进人才科研启动项目，2022R041，基于肠道菌群研究孕期肥胖影响子代代谢健康的作用机制，2022-10至2025-12，15万元，在研，主持。
(2) 国家自然科学基金，青年基金，22006134，基于肠道菌群-胆汁酸-IL22轴研究孕期小鼠暴露抑霉唑和腐霉利对子代的毒理效应，2021-01至2023-12，24万元，在研，主持。
(3) 浙江省博士后科研项目择优资助，一等资助，ZJ2020023，2020-1至2021-12，8万元，结题，主持。
